In response to the growing South African HIV epidemic, a group of local health providers established the countries first paediatric treatment programme for HIV-infected children attached to Groote Schuur Hospital (GSH). Funded and supported by the One to One Children’s Fund, the programme reached 300 children as one of the first paediatric treatment sites in the region. Over 90% of children initiated responded to treatment that was implemented as part of a holistic, family-centred approach. The GSH programme began hosting health provider teams from across South Africa and sub-Saharan Africa, becoming an important learning ground for others who wanted to initiate paediatric treatment programmes. Seeing this peer learning in action inspired the birth of PATA as a knowledge sharing network of paediatric HIV health provider teams and led to the first PATA Forum convened in 2005. PATA was formally registered in 2007.